Preparing Ethers By A Method Called Williamson Synthesis

Purpose: The purpose is to prepare ethers by a method called Williamson synthesis. Reaction Physical Properties Table: Compound MW Amount mmol mp (Â °C) bp(Â °C) d nd p-Cresol 108.15 160 Â µL 1.56 32-34 202 1.02 1.5312 25% NaOH solution 260 Â µL Tetrabutylammonium bromide 322.38 18 mg 0.056 103-104 Propyl iodide 169.99 150 Â µL 1.54 102 1.75 1.5058 Safety: p-cresol Very hazardous in case of skin contact (corrosive, irritant) Hazardous in case of skin contact Skin contact can produce inflammation and blistering sodium hydroxide The substance may be toxic to mucous membranes, upper respiratory tract Severe over-exposure can produce lung damage Very hazardous in case of skin contact, of eye contact, of ingestion, and of inhalation tetrabutylammonium bromide Very hazardous in case of ingestion Slightly hazardous in case of skin contact After contact with skin, wash immediately with plenty of water propyl iodide Cancer suspect agent Harmful if inhaled Causes serious eye irritation diethyl ether Hazardous in case of skin contact Slightly hazardous in case of skin contact Repeated or prolonged exposure to the substance can produce target organs damage anhydrous magnesium sulfate Hazardous in case of ingestion Slightly hazardous in case of skin contact, of eye contact, and of inhalation If inhaled, allow the victim to rest in a well-ve ntilated area methylene chloride Inflammation of the eye is characterized by redness, watering, and itching Repeated or